Endocrine Abstracts

Manuel Tena-Sempere, Spain AbstractThe European Journal of Endocrinology Prize is awarded to a candidate who has significantly contributed to the advancement of the knowledge in the field of endocrinology through publication. This year's recipient is Professor Manuel Tena-Sempere. The prize will be presented as part of the ECE 2011 opening ceremony where Prof. Tena-Sempere will deliver his lectu...

Introduction: Growth hormone deficiency (GHD) associated with a congenital malformation of the hypothalamic-pituitary axis is rare. It can be isolated or part of a combined pituitary deficiency. The purpose of our work is to describe the clinical picture in which between GH deficiency in children.Materials and methods: This is a retrospective study of 18 cases among 192 patients consulting for growth retardation, conducted in the Endocrinology Diabetolog...

Background: Familial Diabetes Insipidus is a very rare entity and can have either neurohypophyseal (FNDI) or nephrogenic forms with different transmission patterns. FNDI accounts for less than 5% of the 1:25 000 cases of DI diagnosed in UK. It is usually an autosomal dominant disorder caused by mutations in AVP (arginine vasopressin) gene, which regulates the vasopressin hormone synthesis; its signs and symptoms of polyuria & polydipsia usually become apparent in childhood...

Introduction: We present a case of neurosarcoidosis presenting with anterior hypopituitarism and hypothalamic syndrome.Case Report: A 38-years old Caucasian woman presented from primary care with six-month history of secondary amenorrhoea. Additionally she reported non-specific tiredness, postural dizziness, nausea and abdominal pains. Over the same period she noticed progressive weight gain of three stones, increased somnolence, lethargy and excessive s...

AimTo evaluate the impact of printed educational materials on knowledge in women with gestational diabetes mellitus (GDM).Materials and methodsA randomized controlled trial was performed among women with GDM. A total of 135 pregnant women with GDM who attended antenatal clinic were randomly assigned to either an intervention (45 pregnant women) or a control group (90 pregnant women). The women from interventi...

In assisted reproduction, poor ovarian response to controlled ovarian stimulation (COS) leads to poor oocyte yield and depends on the genetic background. We compared the expression of key-genes, coding proteins regulating follicular development, between small (<10 mm) and large ovarian follicles (>16 mm), assuming the size as a hallmark of follicle maturation and oocyte fate. Twenty-two patients undergoing COS were enrolled in a fertility clinics. Granulosa cells and folli...

Mechanisms regulating the selection of antral ovarian follicles are poorly understood and supposed to rely on low estrogen levels, decline of follicle-stimulating hormone (FSH) levels and receptor (FSHR) expression on the surface of granulosa cells. These concepts are challenged in-vitro, where apoptosis of human granulosa cells (hGLC) and transfected cell lines is induced by high doses of FSH or FSHR overexpression, while estrogens induce anti-apoptotic signals via n...

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends and plays a role in cellular senescence, being repressed in postnatal somatic cells. Mutations C228T and C250T of the telomerase reverse transcriptase (TERT) were recently reported in human cancers. In thyroid cancer, TERT mutations are more frequent in aggressive histotypes, but very few data are available about the potential correlations with clinical features in papillary and follicular thyroid cancer...

Background: The Chronic Care Model (CCM), developed by Wagner et al., at MacColl Institute for Heathcare Innovation at Group Health Research Institute, Seattle, Washington, United States, is one approach to improving chronic illness care, including diabetes mellitus (DM), that is being used increasingly to assess and improve care. The CCM is based on evidence-based practices and reviews of the literature on effective care. The Patient Assessment of Chronic Illnes...

The prevalence of depressive symptoms in patients suffering from type 2 diabetes is commonly acknowledged. Even mild depression is recognized as clinically relevant for the general health outcomes in this vulnerable patient group. Research in this area has been focused on biochemical markers reflecting common pathological processes of insulin resistance, inflammation and oxidative damage, all being assumed to be interconnected in both diabetes and depression. Most of the studi...